Fig. 3.

Order and orientation of genes syntenic to (A) TLR4,(B) TLR7 and TLR8,(C) TLR12, and (D) TLR1. For unfinished genomes, a small possibility exists that any gene portrayed as absent is actually present. Orthologs are identified by the Human Genome Organisation (HUGO) symbol of the human ortholog. Klotho Beta in humans is GeneID no. 152831. Genes are intentionally aligned in columns to facilitate visualization of synteny. Such alignments help confirm orthology. Select genomes are chosen to illustrate the dynamics of each locus.