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. 2025 Jan 10;16:584. doi: 10.1038/s41467-025-55936-5

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Percentage of CD86⁺ DCs in tracheae of denatonium-treated (1 mM) Trpm5^+/+ (n = 14), controls (n = 7), Trpm5^−/− mice (control n = 6, den n = 16) and Chat^fl/fl:Trpm5^cre mice (control n = 5, den n = 7). Kruskal-Wallis test. B Percentage of CD86⁺ DCs in tracheae of denatonium-treated or control Panx1^+/+ (control n = 4, den n = 6) and Panx1^−/− mice (control n = 4, den n = 5). One-way ANOVA. C Percentage of CD86⁺ DCs in tracheae three days post infection or in uninfected controls in Trpm5^+/+ (control n = 7, P.a. n = 4), Trpm5^−/− (control n = 5, P.a. n = 3) and Panx1^−/− mice (control n = 4, P.a. n = 10). One-way ANOVA. D Percentage of CD86⁺ DCs in lungs of denatonium-treated Trpm5^+/+ (n = 12), control (n = 7), Trpm5^−/− mice (control n = 6, den n = 15) and Chat^fl/fl:Trpm5^cre mice (control n = 5, den n = 7). One-way ANOVA. E Percentage of CD86⁺ DCs in lungs of denatonium-treated or control Panx1^+/+ (n = 5) and Panx1^−/− (n = 4) mice. Unpaired Student’s t-test. F Percentage of CD86⁺ DCs in lungs three days post infection or in uninfected controls of Trpm5^+/+ (control n = 7, P.a. n = 3), Trpm5^−/− (control n = 6, P.a. n = 3) and Panx1^−/− mice (control n = 4, P.a. n = 10). One-way ANOVA. G FACS analysis of T_H17 cells in lungs of denatonium-treated Trpm5^+/+ (n = 7) and Trpm5^−/− (n = 10) mice or controls (Trpm5^+/+ n = 5, Trpm5^−/− n = 6). One-way ANOVA. H T_H17 cell counts from lungs of denatonium-treated and control Panx1^+/+ (control n = 5, den n = 6) and Panx1^−/− mice (control n = 4, den n = 5). One-way ANOVA. I IL-17A levels in plasma samples in control or denatonium-treated Trpm5^+/+ (control n = 4, den n = 5) and Trpm5^−/− (control n = 6, den n = 6) mice. Kruskal-Wallis test. J IL-17A levels in plasma samples of control (n = 5) or denatonium-treated Panx1^+/+ mice (n = 4) or Panx1^−/− mice (control n = 3, den n = 5). Kruskal-Wallis test. Source data are provided in the Source Data file. Data in panels A–J are presented as mean ± SEM.