Figure 9.
The analysis for the toxicity of Il2/ZIF-8@Salmonella to the liver, kidney, and spleen on Day 8 after treatment. (A–D) The histograms showing serum concentrations of ALT (A), AST (B), Crea (C) and Urea (D) in mice treated with indicated regimes. Shigh indicated 107 CFU Salmonella/mouse in this figure and successive figures. n = 3. Data were expressed as mean ± SD. Students' t test was carried out using PBS-treated group as control for each treatment regime. ∗P < 0.05; ∗∗∗P < 0.001; ns, not significant. (E–G) Representative images of H&E staining of spleens (E), kidneys (F), and livers (G) in mice treated with indicated regimes. Scale bar = 100 μm.