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. 2024 Nov 9;14(12):5341–5356. doi: 10.1016/j.apsb.2024.10.017

Figure 1.

Figure 1

Our thio-ProTide-based H2S donor–drug conjugates (DDCs) is structurally distinct from conventional DCCs (A) or other ProTide-based molecules (B, C), providing H2S without lysosomal targeting groups (D).