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. 2024 Nov 9;14(12):5341–5356. doi: 10.1016/j.apsb.2024.10.017

Figure 3.

Figure 3

Liver-specific H2S release of JZ-6 and JZ-HND. (A, B) H2S release from JZ-3, JZ-6, JZ-HND, GYY4137 and Na2S in the rat intestine homogenates (A) and liver homogenates (B). Donors (250 μmol/L) were incubated in homogenates (0.1 g/mL) in PBS (with 2.5% menthol, pH 7.4, 37 °C), then reacted with DNS-N3 (250 μmol/L), followed by fluorescence intensity measurement (λex/λem = 325/450 nm). Data represent the average ± SD (n = 3). (C) AUC ratio of the H2S levels of JZs in intestine and liver homogenates.