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. 2024 Sep 3;14(12):5186–5200. doi: 10.1016/j.apsb.2024.09.001

Figure 6.

Figure 6

Network target of JZOL in the treatment of cough. (A) Dot plot showing pathways in different classifications enriched by molecules related to cough. (B) Bar plot for predicted genes of JZOL in different modules and corresponding sub-modules. (C) Dot plot showing the potential pathways of JZOL in the treatment of cough. (D) TCM-cell-pathway-molecule multilayer network showing the potential mechanism of JZOL on TRP channels of cough, in which red nodes represent the predicted targets of JZOL in TRP channels. (E) Relative expression level of TRPA1 in tracheal tissues of different animal groups. (F) Phenol red excretion of different animal groups. (G) Cough latency and number of coughs of different animal groups. C: control group, M: model group, TRPA1-I: TRPA1 inhibitor group, Amb: Ambroterol oral solution group, Ami: Aminophylline group, JZ-L: JZOL low dose group, JZ-M: JZOL middle dose group, JZ-H: JZOL high dose group. Data are presented as mean ± SD. ∗P < 0.05, ∗∗P < 0.01 (vs model group); #P < 0.05, ##P < 0.01 (vs control group).