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. 2025 Jan 8;19:111–128. doi: 10.2147/DDDT.S478692

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© 2025 Duan et al.

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LY294002 reverses the anti-apoptotic effect of remimazolam in brain ischemia/reperfusion (I/R) injury. (A) Flow cytometry apoptosis results of SY5Y cells in each group. (B) Cell apoptosis rate. n=3. (C) Bcl2, Bax, Cleaved-Caspase 3 and Caspase 3 protein bands in the tissue of the ischemic penumbra region of rat brain in each group. Protein relative expression: (D) Bax, (E) Bcl2. Protein ratio: (F) Bax/Bcl2, (G) Cleaved-Caspase 3/Caspase 3. (H) Results of TdT-mediated dUTP Nick-End Labeling (TUNEL) immunofluorescence staining of neuronal cells in the ischemic cerebral cortex of rats in each group. (I) Percentage of TUNEL-positive neuronal cell counts. n=3. *P<0.05, **P<0.01, ***P<0.001.