Table 3.
Preparation of T315I series in DNA mutation abundance testing.
Mutation abundance (Mutation/wild copies/μL) | Input serial DNA mutation abundance (μL) |
|||||
---|---|---|---|---|---|---|
29.20%* | 10% | 5% | 1% | 0.1% | 0%# | |
10% (497/4470) | 15 | 25 | ||||
5% (255/4836) | 10 | 42 | ||||
1% (52/5142) | 5 | 43 | ||||
0.50% (26/5181) | 5 | 44 | ||||
0.10% (5/5212) | 5 | 45 | ||||
0.02% (1/5218) | 5 | 20 |
T315I BCR::ABL mutation (1327 copies/μL) - wild BCR::ABL (3217 copies/μL).
wild BCR::ABL DNA sample (5220 copies/μL).