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editorial
. 2025 Jan 12;15(1):e70186. doi: 10.1002/ctm2.70186

FIGURE 2.

FIGURE 2

Schematic illustration of the immune response in the lung TME and systemic T cell protection post‐IL12 therapy. IL12‐Exo treatment primarily induced IFN‐γ expression in CD8+ T cells, with some expression also observed in natural killer T (NKT) cells. Granzyme B expression was induced in these two cell types, equipping them with direct tumour‐killing ability. Additionally, IL12‐Exo therapy activated systemic T cell protection. In specific, it enhanced the expression of cDC1 cells, followed by antigen priming in the lymph nodes, leading to tumour‐specific antigen expression on peripheral CD8+ T cells. The figure was created with BioRender.com.