Table 1.
Patient characteristics
| Total | Model development | Model evaluation | |||
|---|---|---|---|---|---|
| CA | Non-CA | CA | Non-CA | ||
| Subject, n | 166 | 51 | 60 | 25 | 30 |
| Age, years | 70 [58–79] | 78 [71–82] | 63 [53–70] | 78 [64–82] | 60 [45–72] |
| Female, n (%) | 48 (28.9) | 12 (24.0) | 20 (32.8) | 5 (19.2) | 11 (37.9) |
| Etiologies, n (%) | |||||
| Amyloidosis | 76 (45.8) | 50 (100.0) | 26 (100.0) | ||
| HCM | 13 (7.8) | 10 (16.4) | 3 (10.3) | ||
| DCM | 12 (7.2) | 8 (13.1) | 4 (13.8) | ||
| HHD | 12 (7.2) | 4 (6.6) | 8 (27.6) | ||
| VHD | 10 (6.0) | 5 (8.2) | 5 (17.2) | ||
| Post-transplant | 9 (5.4) | 8 (13.1) | 1 (3.4) | ||
| Cardiac sarcoidosis | 8 (4.8) | 6 (9.8) | 2 (6.9) | ||
| Others, undiagnosed | 26 (15.7) | 20 (32.8) | 6 (20.7) | ||
| Amyloid classification, n (%) | |||||
| ATTR | 54 (71.1) | 34 (68.0) | 20 (76.9) | ||
| AL | 10 (13.2) | 9 (18.0) | 1 (3.8) | ||
| AA | 9 (11.8) | 6 (12.0) | 3 (11.5) | ||
| ATTR and AL | 3 (3.9) | 1 (2.0) | 2 (7.7) | ||
| Prior HF hospitalization, n (%) | 53 (31.9) | 17 (34.0) | 22 (36.1) | 8 (30.8) | 6 (20.7) |
| PM, ICD, CRT, n (%) | 29 (17.5) | 4 (8.0) | 18 (29.5) | 4 (15.4) | 3 (10.3) |
| Moderate to severe AS, n (%) | 13 (7.8) | 3 (6.0) | 1 (1.6) | 3 (11.5) | 6 (20.7) |
| Rhythm, n (%) | |||||
| Sinus | 116 (69.9) | 29 (58.0) | 47 (77.0) | 15 (57.7) | 25 (86.2) |
| AF | 39 (23.5) | 18 (36.0) | 9 (14.8) | 8 (30.8) | 4 (13.8) |
| PM | 9 (5.4) | 2 (4.0) | 5 (8.2) | 2 (7.7) | 0 (0.0) |
| SBP, mm Hg | 113 [102–129] | 110 [100–121] | 122 [103–137] | 114 [103–127] | 115 [103–127] |
| DBP, mm Hg | 70 [60–76] | 62 [58–71] | 70 [62–85] | 70 [60–74] | 72 [66–80] |
| Heart rate, bpm | 70 [61–80] | 67 [62–75] | 69 [60–82] | 73 [61–78] | 78 [66–86] |
| BNP, pg/mL | 216 [104–483] | 288 [154–532] | 159 [58–440] | 216 [138–333] | 225 [125–694] |
| LVEF (%) | 49 [38–63] | 48 [41–61] | 49 [36–65] | 50 [42–66] | 43 [32–58] |
| IVST (mm) | 11 [9–15] | 15 [12–16] | 10 [8–11] | 14 [10–16] | 10 [9–11] |
| LVPWT (mm) | 11 [9–14] | 14 [12–16] | 9 [9–11] | 14 [10–16] | 10 [9–11] |
| LAD (mm) | 42 [36–48] | 44 [40–48] | 42 [35–46] | 43 [36–48] | 40 [34–48] |
Data are presented as n (%) or median [Q1–Q3].
HCM, hypertrophic cardiomyopathy; DCM, dilated cardiomyopathy; HHD, hypertensive heart disease; VHD, valvular heart disease; PM, pacemaker; ICD, implantable cardioverter defibrillator; CRT, cardiac resynchronization therapy; AS, aortic valve stenosis; AF, atrial fibrillation; SBP, systolic blood pressure; DBP, diastolic blood pressure; BNP, brain natriuretic peptide; LVEF, left ventricular ejection fraction; IVST, interventricular septum thickness; LVPWT, left ventricular posterior wall thickness; LAD, left atrial dimension.