Figure 1.

Comprehensive overview of potassium channel-targeting conotoxins and their structural/functional relationships. The figure uses a radial organization around a central Conus shell, presenting information in three concentric layers: Inner layer, names of the toxins. Middle layer, structural information: conotoxin structures are shown as ribbon diagrams; experimentally determined structures (Protein Data Bank) are displayed in the color scheme that appears in the thumbnail images of each toxin, while computational predictions (PEP-FOLD3) appear in gray. Outer layer, evidence classification: Target subtype (connecting lines indicate validated interactions with specific potassium channel targets; multiple connections highlight toxins with broad-spectrum activity), “By in vivo bioassays” (Toxins validated through functional studies), “By similarity” (candidate toxins identified through sequence homology analysis), or “By effect on potassium currents” (toxins with demonstrated electrophysiological effects).