Table 2.
Peptide toxins isolated from marine Conus species targeting voltage-gated potassium (Kv) channel subtypes.
| Toxin | Target Potassium Channel(s) (*IC50, °Kd, ^EC50) | References |
|---|---|---|
| κO-PVIIA | *Shaker (60 nM) | [18] |
| κO-SrVIA | *hKv1.6 (3.6 µM); *hKv10.1 (1.88 µM); *hKv11.1 (2.44 µM) | [26] |
| κM-RIIIK | *Shaker (1.21 µM); *TSha1 (73 nM); *hKv1.2 (352 nM); *rKv1.2 (335 nM) | [32,33,34] |
| κM-RIIIJ | *hKv1.2 (33 nM); *hKv1.3 (10µM); *hKv1.5(70µM); *hKv1.6 (8 µM); *rKv1.1 (4 µM) | [35] |
| ĸA-SIVA | *Shaker (≈50% current decrease at 2.5 μM) | [27] |
| Vt3.1 | *rat α-mslo1 + hβ4 (8.5 µM) | [38] |
| α/κJ-PlXIVA | *Kv1.6 (1.59 µM) | [40] |
| κI2-ViTx | °rKv1.1 (1.59 µM); °hKv1.3 (2.09 µM) | [41] |
| κI2-BtX | ^KCa (0.7 nM) | [42] |
| κI2-SrXIA | *rKv1.2 (66% current decrease at 640 nM); *hKv1.6 (58% current decrease at 640 nM) | [44] |
| κ-CPY-Pl1 | *Kv1.6 (170 nM); *Kv1.2 (2 µM) | [50] |
| Κ-CPY-Fe1 | *Kv1.6 (8.8 µM) | [50] |
| CNF-Sr3 | °Shaker (2.7 µM); *hKv1.6 (2.7 µM); *hKv1.3 (24 µM) | [53,54] |
| Conk-S1 | *Shaker-∆6–46 (502 nM); *mKv1.7(439 nM) | [6,56] |
| Conk-C3 | *Shaker (50% current decrease at 500 nM) | [57] |