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HIV-2 leader RNA secondary structure model. The model of the 5′ untranslated leader RNA of the HIV-2 isolate ROD is adapted from Berkhout (31). The hairpin structures are named according to their putative function in HIV-1 replication, and several critical sequence elements are highlighted in gray (the polyadenylation signal, the PBS and the DIS palindrome). The Gag start codon at position 545 is boxed. Positions used in this study as 5′/3′ transcript ends are marked.
