Table 2. Interactions of fexofenadine with the active site of RdRp.

Functional group	Residue	Bond	Distance (Å)
Carboxylic acid	Trp617	H-bond (D-S)	2.91
Carboxylic acid	Trp800	H-bond (D-B)	2.76
Carboxylic acid	Glu811	H-bond (A-B)	2.02
‘Phenyl	Tyr455	Hydrophobic/Pi-Pi T-form	5.57
‘Phenyl	Arg553	Electrostatic/pi-cation	4.38
‘Phenyl	Lys621	Electrostatic/pi-cation	4.62
‘Phenyl	Arg624	Hydrophobic/pi-alkyl	3.09
‘’Phenyl	Lys621	Electrostatic/pi-cation	5.46
Butyl	Asp760	Carbon hydrogen bond	3.59

For amino acid, A: H-bond acceptor, D: H-bond donor, B: Backbone interaction, S: Sidechain interaction. Light green: Carbon hydrogen bond, Green: H-bond, Orange: Electrostatic interactions, Pink: Hydrophobic interactions, RdRp: RNA-dependent RNA polymerase