Figure 8.

(A) Time-dependent radiation-induced increase in p90RSK phosphorylation. Cells were irradiated with 2 Gy and incubated for various times, and extracts were analyzed by Western blotting. The top panel shows phospho-p90RSK, and the bottom panel shows the same blot probed for β-actin. (B) Inhibition of p90RSK phosphorylation at 30 min after irradiation by either AG1478 or PD98059. Fold-changes represent the mean of three independent experiments. The fold-change at 30 min and inhibition by either compound were significant (p < 0.05).