Fig. 2.

Mechanisms of action of antibody complex. This figure illustrates the mechanisms of four distinct types of antibody complexes. (A) T cell recruitment. This class of antibodies facilitates the recruitment of T lymphocytes to target and attack cancer cells. (B) Enhanced immune responses. Beyond T cell recruitment, antibodies in this class possess Fc regions that mediate ADCC, ADCP, and CDC effects. (C) Dual cancer cell antigen targeting. Antibodies of this class are designed to target two distinct antigens on cancer cell, potentially enhancing their therapeutic efficacy. (D) Antibody-drug conjugates. These antibodies are capable of killing cancer cells by delivering a cytotoxic payload while also stimulating immune cells. Abbreviations: ADCC, antibody-dependent cellular cytotoxicity; ADCP, antibody-dependent cellular phagocytosis; CDC, complement-dependent cytotoxicity; MAC, membrane attack complex, ADC, antibody-drug conjugates. Created with BioRender.com.