Table 2.
Baseline characteristics of all-cause mortality dataset
| Characteristics | Ferritin (ng/mL) | P value | TSAT (%) | P value | ||||
|---|---|---|---|---|---|---|---|---|
| Overall, n = 16,566 | ≤ 100, n = 4,398 | > 100, n = 12,168 | Overall, n = 4,730 | ≤ 20, n = 653 | > 20, n = 4,077 | |||
| Follow-up, months | 49.5 [21.1, 73.4] | 48.7 [20.3, 72.4] | 49.8 [21.6, 73.6] | 0.170 | 25.7 [6.8, 49.5] | 21.4 [3.7, 45.3] | 26.4 [7.6, 50.0] | 0.002 |
| Age, years | 58.0 [45.0, 69.0] | 50.0 [38.0, 66.0] | 60.0 [48.0, 70.0] | < 0.001 | 53.0 [39.0, 66.0] | 53.0 [38.0, 67.0] | 53.0 [39.0, 65.0] | 0.965 |
| Sex, female, n (%) | 6,834 (41.3) | 2,849 (64.8) | 3,985 (32.7) | < 0.001 | 2,067 (43.7) | 390 (59.7) | 1,677 (41.1) | < 0.001 |
| Charlson score | 4.0 [2.0, 6.0] | 3.0 [1.0, 5.0] | 4.0 [2.0, 6.0] | < 0.001 | 3.0 [1.0, 4.0] | 3.0 [1.0, 4.0] | 3.0 [1.0, 4.0] | 0.501 |
| Laboratory tests | ||||||||
| Ferritin, ng/mL | 177.1 [95.1, 285.3] | 58.8 [35.9, 79.3] | 229.2 [158.4, 322.6] | < 0.001 | 179.1 [92.0, 283.0] | 119.5 [47.5, 253.0] | 186.5 [102.3, 288.1] | < 0.001 |
| TSAT, % | 31.8 [24.2, 40.7] | 27.8 [20.6, 37.1] | 33.0 [25.9, 42.1] | < 0.001 | 31.3 [24.0, 39.9] | 16.8 [13.9, 18.6] | 33.3 [27.3, 41.6] | < 0.001 |
| Scr, µmol/L | 85.0 [65.8, 111.0] | 75.0 [58.0, 103.0] | 88.0 [69.0, 113.7] | < 0.001 | 91.0 [73.0, 116.0] | 94.0 [72.0, 125.0] | 91.0 [73.5, 115.0] | 0.175 |
| eGFR, ml/min per 1.73m2 | 58.0 [45.0, 69.0] | 50.0 [38.0, 66.0] | 60.0 [48.0, 70.0] | < 0.001 | 53.0 [39.0, 66.0] | 53.0 [38.0, 67.0] | 53.0 [39.0, 65.0] | 0.967 |
| Proteinuria, n (%) | < 0.001 | 0.004 | ||||||
| ≥ 1+ | 8,594 (51.9) | 2,552 (58.0) | 6,042 (49.7) | 2,453 (51.9) | 313 (47.9) | 2,140 (52.5) | ||
| Trace | 6,890 (41.6) | 1,545 (35.1) | 5,345 (43.9) | 2,093 (44.2) | 301 (46.1) | 1,792 (44.0) | ||
| NA | 1,082 (6.5) | 301 (6.8) | 781 (6.4) | 184 (3.9) | 39 (6.0) | 145 (3.6) | ||
| CRP (mg/L), n (%) | < 0.001 | < 0.001 | ||||||
| ≤ 10 | 10,306 (62.2) | 3,058 (69.5) | 7,248 (59.6) | 3,837 (81.1) | 420 (64.3) | 3,417 (83.8) | ||
| > 10 | 1,622 (9.8) | 248 (5.6) | 1,374 (11.3) | 421 (8.9) | 164 (25.1) | 257 (6.3) | ||
| NA | 4,638 (28.0) | 1,092 (24.8) | 3,546 (29.1) | 472 (10.0) | 69 (10.6) | 403 (9.9) | ||
| Hb, g/L | 140.0 [132.0, 150.0] | 136.0 [129.0, 145.0] | 141.0 [133.0, 151.0] | < 0.001 | 139.0 [131.0, 149.0] | 134.0 [128.0, 143.0] | 140.0 [132.0, 150.0] | < 0.001 |
| GLU, mmol/L | 5.5 [4.8, 7.0] | 5.3 [4.7, 6.4] | 5.6 [4.9, 7.3] | < 0.001 | 5.3 [4.6, 6.6] | 5.5 [4.7, 6.8] | 5.2 [4.6, 6.5] | 0.001 |
| TCHO, mmol/L | 4.9 [4.1, 5.9] | 4.8 [4.0, 5.8] | 4.9 [4.1, 5.9] | 0.055 | 5.0 [4.2, 6.1] | 4.8 [4.0, 5.7] | 5.0 [4.3, 6.1] | < 0.001 |
| ALB, g/L | 39.9 [35.9, 43.0] | 39.6 [35.5, 42.6] | 40.0 [36.0, 43.2] | < 0.001 | 39.1 [35.3, 42.4] | 38.8 [35.2, 41.7] | 39.2 [35.3, 42.5] | 0.114 |
| Comorbidities | ||||||||
| Hypertension, n (%) | 7,721 (46.6) | 1,749 (39.8) | 5,972 (49.1) | < 0.001 | 2,155 (45.6) | 306 (46.9) | 1,849 (45.4) | 0.499 |
| Diabetes, n (%) | 4,196 (25.3) | 835 (19.0) | 3,361 (27.6) | < 0.001 | 944 (20.0) | 161 (24.7) | 783 (19.2) | 0.001 |
| Cancer, n (%) | 1,669 (10.1) | 467 (10.6) | 1,202 (9.9) | 0.171 | 410 (8.7) | 58 (8.9) | 352 (8.6) | 0.893 |
| Liver disease, n (%) | 4,667 (28.2) | 975 (22.2) | 3,692 (30.3) | < 0.001 | 983 (20.8) | 128 (19.6) | 855 (21.0) | 0.454 |
| CVD, n (%) | 5,410 (32.7) | 1,118 (25.4) | 4,292 (35.3) | < 0.001 | 1,337 (28.3) | 219 (33.5) | 1,118 (27.4) | 0.001 |
| PVD, n (%) | 4,174 (25.2) | 903 (20.5) | 3,271 (26.9) | < 0.001 | 821 (17.4) | 98 (15.0) | 723 (17.7) | 0.099 |
| Infection, n (%) | 1,374 (8.3) | 269 (6.1) | 1,105 (9.1) | < 0.001 | 291 (6.2) | 27 (4.1) | 264 (6.5) | 0.026 |
| Prescription drugs | ||||||||
| RASi, n (%) | 6,686 (40.4) | 1,815 (41.3) | 4,871 (40.0) | 0.157 | 2,139 (45.2) | 302 (46.2) | 1,837 (45.1) | 0.600 |
| Diuretics, n (%) | 3,193 (19.3) | 868 (19.7) | 2,325 (19.1) | 0.377 | 766 (16.2) | 125 (19.1) | 641 (15.7) | 0.032 |
| Statins, n (%) | 5,763 (34.8) | 1,258 (28.6) | 4,505 (37.0) | < 0.001 | 1,688 (35.7) | 224 (34.3) | 1,464 (35.9) | 0.453 |
| Chemotherapy, n (%) | 1,286 (7.8) | 326 (7.4) | 960 (7.9) | 0.327 | 332 (7.0) | 57 (8.7) | 275 (6.7) | 0.078 |
Results are expressed as median [interquartile range] or number (percentage)
Scr: serum creatinine; eGFR: estimated glomerular filtration rates; CRP: C-reactive protein; Hb: hemoglobin; TCHO: total cholesterol; ALB: albumin; CVD: cardiovascular and cerebrovascular disease; PVD: peripheral vascular disease; RASi: renin-angiotensin-aldosterone system inhibitor