Table 3.

Associations of ferritin and TSAT levels with risks for outcomes

	Event/N (%)	Crude HR (95% CI)	P value	Adjusted HR (95% CI)	P value
Chronic kidney disease progression
Ferritin (ng/mL)
≤ 100	248/2,450 (10.1)	0.86 [0.74, 0.99]	0.035	1.11 [0.96, 1.29]	0.170
> 100	772/6,545 (11.8)	Reference		Reference
TSAT (%)
≤ 20	44/320 (13.8)	1.55 [1.12, 2.15]	0.009	1.66 [1.16, 2.37]	0.005
> 20	195/2,120 (9.2)	Reference		Reference
All-cause mortality
Ferritin (ng/mL)
≤ 100	432/4,398 (9.8)	0.86 [0.78, 0.96]	0.008	1.10 [0.99, 1.23]	0.087
> 100	1403/12,168 (11.5)	Reference		Reference
TSAT (%)
≤ 20	29/653 (4.4)	2.75 [1.79, 4.22]	< 0.001	2.21 [1.36, 3.57]	0.001
> 20	76/4,077 (1.9)	Reference		Reference

Chronic kidney disease progression: adjusted for sex, age, eGFR, proteinuria, albumin, C-reactive protein, hemoglobin, total cholesterol, Charlson score, diabetes, hypertension, cardiovascular and cerebrovascular disease, liver disease, cancer, statins, and renin-angiotensin-aldosterone system inhibitor

All-cause mortality: adjusted for sex, age, eGFR, proteinuria, albumin, C-reactive protein, hemoglobin, total cholesterol, Charlson score, diabetes, hypertension, cardiovascular and cerebrovascular disease, liver disease, and cancer