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. 2002 Jan 8;99(2):585–590. doi: 10.1073/pnas.012611299

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Copyright © 2002, The National Academy of Sciences

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A model for in vitro IleRS tRNA-mediated editing in which one round of posttransfer editing precedes multiple rounds of pretransfer editing. (i) tRNA^Ile binds to the IleRS/Val-AMP complex. (ii) Valine is covalently transferred to tRNA^Ile. (iii) The acceptor stem of Val-tRNA^Ile is translocated to the editing site. (iv) Val-tRNA^Ile is hydrolyzed and valine is released. A second molecule of Val-AMP is synthesized at the aminoacylation site. (v) Val-AMP is translocated to the editing site. (vi) Val-AMP is hydrolyzed at the editing site, and a third molecule of Val-AMP is synthesized at the aminoacylation site. (vii) Val-AMP is translocated to the editing site, and the cycle is repeated.