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Delayed human globin switching. Primer extension assay of fetal liver globin RNA from E13.5 and E17.5 Ikaros null mice transgenic for the human β-locus cosmid (see Materials and Methods). Human fetal to (fetal + adult) globin ratios from primer extension data at E13.5 (Left) and E17.5 (Right). Transgenic null mice have relatively higher persistence of human fetal globin RNA at both stages during development. At E13.5: +/+, n = 4; −/−, n = 3. At E17.5: +/+, n = 5; −/−, n = 2.
