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. 2025 Jan 15;272(2):132. doi: 10.1007/s00415-024-12876-2

Table 4.

Interaction and main effects of Δ VPT, Δ sway, and Δ GM volume over time

Cluster Brain region Cluster size MNI
x, y, z
Statistic value
Voxel-based morphometry analysis
Interaction of Δ VPT, Δ sway, and Δ GM volume over time
1 Left supplementary motor cortex 115 −4 3 54 F = 57.66**
2 Left precuneus 371 −4 −51 64 F = 56.11**
3

Left supplementary motor cortex,

Left paracentral lobule,

Right supplementary motor cortex

64 0 −9 72 F = 52.31**
4 Left precentral gyrus 10 −20 −10 74 F = 48.96**
5

Left middle frontal gyrus,

Left superior frontal gyrus dorsolateral

20 −26 27 46 F = 48.36**
6

paracentral lobule,

Right paracentral lobule,

Left postcentral gyrus,

Left precuneus

68 −4 −32 75 F = 45.56**
7 Left precuneus 11 −2 −76 52 F = 41.78*
Conditional main effect of Δ VPT
1

Left supplementary motor area

Left paracentral lobule

Right supplementary motor area

82 0 −9 72 F = 56.16**
2

Right paracentral lobule

Left paracentral lobule

24 24 2 −28 F = 46.25**
3 Left precentral gyrus 2 −20 −12 75 F = 42.18**
4 Left supplementary motor area 3 −3 3 52 F = 41.23*
Conditional main effect of Δ sway
1

Left supplementary motor area

Right supplementary motor area

Left paracentral lobule

25 0 −10 74 F = 46.46**
Diffusion tensor imaging analysis
Interaction of Δ VPT, Δ sway, and Δ FA values over time
1 Splenium of corpus callosuma, forceps majorb 215 11.6, −39.6, 21
2 Right corticospinal tractb 12 22.3, −31.2, 47.6
3 Body of corpus callosuma 5 2.6, −25.8, 22

Δ: Change; FA: fractional anisotropy; − not available (as TFCE correction does not result in t values and associated degrees of freedom)

*FWE Corrected P < 0.05

**FWE corrected P < 0.0166 (corrected for 3 imaging contrasts/comparisons)

TFCE corrected P < 0.0083 (corrected for 6 imaging contrasts/comparisons)

aICBM-81 atlas [36, 37]

bJHU white-matter tractography atlas [38, 39]