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. 2024 Dec 27;13(12):3407–3425. doi: 10.21037/tlcr-24-463

Figure 2.

Figure 2

Construction of a 4-NFRG-based prognostic signature. (A) Heatmap showing differential expression of 21 NFRGs between LUAD and control tissue samples. Red represents high expression, and blue represents low expression. (B) Forest plot showing univariate Cox regression analyses of NFRGs on the overall survival of LUAD patients. (C) Protein level expression of NFRGs in the UALCAN database of LUAD patients (data from the CPTAC database). (D) Coefficients of four NFRGs were selected by the lambda with the minimum binomial deviance marked by the black dashed line [ln(lambda) = −4.6]. (E) The LASSO binomial model fitting process. Each curve represents a variable. (F) Table showing genes and corresponding coefficients in the prognostic model. Student’s t-test was used to generate a P value. The P value cutoff was 0.05. *, P<0.05; **, P<0.01; ***, P<0.001. NFRG, neutrophil extracellular trap formation-related genes; LUAD, lung adenocarcinoma; Coef, coefficients; LASSO, least absolute shrinkage and selection operator; UALCAN, University of ALabama at Birmingham CANcer data analysis Portal.