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Ventilatory responses to acute hypoxia and hyperoxia. RR, VT, and VE were measured in unanesthetized wild-type Hif1a+/+ (open bars) and Hif1a+/− (closed bars) mice (n = 8 each) during exposure to inspired gas mixtures containing the indicated concentrations of O2 (A) and CO2 (B). Representative tracings of VT are shown (Upper). Ventilatory data are expressed (mean ± SEM) relative to values obtained while breathing 100% O2 (Lower).
