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. Author manuscript; available in PMC: 2025 Jan 17.
Published in final edited form as: Physiol Behav. 2023 Dec 10;275:114431. doi: 10.1016/j.physbeh.2023.114431

Table 2.

Summary of fold change IMF treatment differences in gene expression in the ARC, LH, and LC between male and female 12-month-old and 18-month-old mice. .

Region Gene 12-month-old 18-month-old
Male Female Male Female
ARC Agrp ↑ n.s. n.s. n.s.
Npy ↑ n.s. ↑ n.s.
Hcrtrl n.s. n.s. n.s. n.s.
Adrla ↓ n.s. ↓ n.s.
Adrlb n.s. n.s. n.s. n.s.
Kcnq3 n.s. n.s. n.s. n.s.
Kcnq5 n.s. n.s. n.s. n.s.
Pomc n.s. n.s. n.s. n.s.
Cart n.s. n.s. n.s. ↓ trend
LH Hcrt n.s. n.s. n.s. ↓
Npylr ↓ ↓ n.s. n.s.
Npy5r ↓ n.s. n.s. n.s.
Adrla ↓ n.s. n.s. n.s.
Adrlb ↓ n.s. n.s. n.s.
LC Slc6a2 n.s. n.s. n.s. n.s.
Dbh n.s. n.s. n.s. n.s.
Hcrtrl n.s. n.s. n.s. n.s.

Adr1a, alpha-1A adrenergic receptor; Adr1b, alpha-1B adrenergic receptor; Agrp, agouti-related protein; ARC, arcuate nucleus; Cart, cocaine- and amphetamine-regulated transcript; Dbh, dopamine β-hydroxylase; Hcrt, hypocretin neuropeptide precursor; Hcrtr1, hypocretin receptor 1; Kcnq2, potassium voltage-gated channel subfamily Q member 2; Kcnq3, potassium voltage-gated channel subfamily Q member 3; Kcnq5, potassium voltage-gated channel subfamily Q member 5; LC, locus coeruleus; Npy, neuropeptide Y; Npy1r, neuropeptide Y receptor 1; Npy2r, neuropeptide Y receptor 2; Pomc, proopiomelanocortin; Slc6a2, solute carrier family 6 member 2. ↑ = increased fold change in gene expression IMF-treated mice in contrast to controls; ↓ = decreased fold change in gene expression in IMF-treated mice in contrast to controls; n.s. = not significant.