Table 3.
γ radiation-induced G2 phase chromosome aberrations in control cells (C3ABR) transfected with wild-type or mutant ATM constructs
| Cell line | Aberrations, no.
|
No. ICAs per metaphase | ||
|---|---|---|---|---|
| sb | cb | Int | ||
| C3ABR | 54 | 2 | 0 | 1.12 |
| AT1ABR | 168 | 1 | 0 | 3.38 |
| C3ABR + Wild-type | 57 | 0 | 0 | 1.14 |
| C3ABR + SRI2546del3 | 145 | 0 | 1 | 2.92 |
| C3ABR + V2716A | 147 | 2 | 0 | 2.98 |
| C3ABR + R2849P | 150 | 0 | 0 | 3.00 |
| C3ABR + G2867R | 149 | 1 | 1 | 3.02 |
| C3ABR + A2274T | 58 | 1 | 0 | 1.18 |
| C3ABR + G2287A | 61 | 1 | 0 | 1.24 |
| C3ABR + C2464R | 59 | 0 | 2 | 1.22 |
| C3ABR + S2592C | 143 | 2 | 1 | 2.90 |
| C3ABR + V2662del | 58 | 0 | 1 | 1.18 |
| C3ABR + G2772R | 63 | 1 | 0 | 1.28 |
sb, chromatid breaks; cb, chromosome breaks; Int, interchanges. Fifty metaphases were analyzed for each sample after exposure to 1 Gy of radiation and in the presence of CdCl2. Data for ICAs are the mean.