Fig. 6.

Variable CNV and gene expression patterns in LumAcinar cells from human prostate adenocarcinomas. A UMAP plot of the epithelial populations from 2 healthy prostates [13], 3 prostates with BPH [7], and 17 prostates with treatment-naive PCa from Memorial Sloan Kettering Cancer Center [6] and Shanghai Changhai Hospital [17]. B Dot plot of key prostate cell type and cancer markers. C Immunofluorescence staining of varying levels of MSMB (green) in LumAcinar cells across multiple prostate zones. MSMB is expressed at high levels in normal LumAcinar cells, but is reduced or absent in abnormal acinar areas where basal cells expressing CK5 (red) are intact (yellow arrows), and in tumor-containing areas where basal cells are absent (white arrow)