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. 2002 Jan 15;99(2):931–936. doi: 10.1073/pnas.022634999

Figure 3.

Figure 3

Repetitive TP-DC immunization can prevent MT-901 breast tumor growth and elicit specific IFN-γ-producing immune cells when initiated early post-BMT. (A) TP-DC groups were immunized thrice weekly starting on day 7 post-BMT. Immunized and control mice were challenged with two different doses of viable MT-901 tumor cells at 4 weeks post-BMT. Data are reported as the average tumor size ± SEM of five mice per group and are representative of two experiments (P < 0.01). (B) Tumor-specific IFN-γ production in BMT mice immunized with MT-901 TP-DC. Spleens were harvested 7 days after the third vaccine injection. Responder spleen cells (NT or TP-DC) were cultured with either irradiated MT-901 or A20 irrelevant tumor. After 48 h, culture supernatants were collected and the amount of IFN-γ was measured by standard ELISA method. Data are reported in pg/ml (mean ± SEM of triplicate samples) and are representative of two experiments (P < 0.03).