Table 2.

H. influenzae putative essential genes conserved in M. tuberculosis and absent in S. cerevisae

Hin	Mtu	Bsu	Mge	Cpn	Ctr	Nme	Cje	Hpy	Eco	Pmu	Pae	Vch	Bbu	Tpa	PROSITE
HI0004	+	+	+E	+	+	+	+	+	+N	+	+	+	+	+	UPF0054
HI0175	+	+N		+	+	+	+		+	+	+	+	+
HI0303	+	+				+	+	+	+	+	+	+	+	+
HI0338	+	+				+			+	+	+	+	+		Predicted transmembrane
HI0466	+					+			+	+	+	+
HI0570	+								+	+	+	+
HI0767	+	+N		+	+	+	+	+	+N	+	+	+	+	+	N6_MTASE
HI1086	+					+			+	+	+	+			PROKAR_LIPOPROTEIN
HI1282	+	+N				+	+	+	+N	+	+	+	+	+
HI1608	+	+E			+	+	+	+	+E	+	+	+		+
HI1654	+	+N	+E			+	+	+	+N	+	+N	+	+	+	UPF0011
HI1731	+					+	+		+		+	+

Presence (+) or absence (blank) of homologs to putatively essential H. influenzae proteins in a range of other bacteria. Homologs of H. influenzae proteins included or excluded from the table yielded PAM250 DP values > 80 and P values <10⁻³ based on precomputed blastp comparisons of 37 microbial genomes (http://mbgd.genome.ad.jp/). Growth phenotypes previously determined for mutants deficient in homologs in other species (see text) are summarized as essential (E) or nonessential (N) when data are available. H. influenzae (hin), M. tuberculosis (mtu), B. subtilis (bsu), Chlamydia pneumoniae (cpn), Chlamydia trachomatis (ctr), N. meningitidis (nme), Campylobacter jejuni (cje), H. pylori (hpy), E. coli (eco), Pasteurella multocida (pmu), P. aeruginosa (pae), V. cholerae (vch), Borrelia burgdorferi (bbu), and Treponema pallidum (tpa).