Figure 3.

LTD by prolonged mGluR2 activation in visual cortex but not CA1. (A) Two-pathway recording configuration with representative traces before and after DCG-IV. Control input was stopped during drug application, whereas test stimulation continued at baseline frequency (0.1 Hz). (Scale bar = 500 μV, 5 ms.) (B) Only test input (●, six slices, six mice) is persistently depressed after DCG-IV (1 μM, 20 min) washout from bath. Note unaltered control path (○). (C) Subsequent LFS fails to induce LTD along previously depressed test path (●, five slices), whereas control input is still susceptible (○, four slices). (D) Prolonged DCG-IV (1 μM, 20 min) exposure does not persistently depress synaptic transmission in WT hippocampal area CA1 (six slices).