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. 2002 Jan 22;99(2):1041–1046. doi: 10.1073/pnas.022618799

Figure 5.

Figure 5

Ocular dominance plasticity in the absence of mGluR2. (A) Typical contralateral eye bias (ocular dominance <4) of WT (Upper, 96 cells, four mice) shifts toward open, ipsilateral eye after brief MD during critical period (Lower, 82 cells, four mice). (B) mGluR2 KO shift similarly after MD (Upper, nondeprived: 93 cells, four mice; Lower, MD: 185 cells, eight mice). The contralateral bias index (range 0–1, upper right corner) decreases from typically high values in mice when MD is effective (3, 11, 12, 36). (C) Ocular dominance plasticity is unimpaired in mGluR2 KO mice treated during MD with vehicle (Upper, 50 mM NaOH intracerebroventricularly; 115 cells, five mice) or group I mGluR antagonist (Lower, 50 mM AIDA, intracerebroventricularly; 133 cells, six mice).