Figure 1. Flowchart of the Study.

Control cohorts are either from (1) in-house control luminal B BCs for the RNA-seq and IHC analyses, (2) the COSMIC database¹⁴ for the DNA sequencing of NOVA1 and NOVA2, or (3) a literature-drawn cohort⁹ for the clinicopathologic comparison. BC = breast cancer; CGHa = Comparative Genomic Hybridization array; HER2- = no overexpression of human epidermal growth factor receptor 2; COSMIC = Catalogue of Somatic Mutations in Cancer; HR+ = overexpression of hormone receptor; IHC = immunohistochemistry; PNS = paraneoplastic neurologic syndrome; TNM = tumor node metastasis staging.