Table 5.
Comparison of PpIX-TSLT variables between patients and matched controls.
| All patients and matched controls |
FDR adj. p value |
Trajectory N=21 |
FDR-adj. P value |
||
|---|---|---|---|---|---|
| T0: preoperative | |||||
| Age (years) | controls | 40.0 [29.0-64.0]; n=41 | 0.87 | 53.0 [31.0-65.0] | 0.68 |
| patients | 47.0 [37.0-56.0]; n=41 | 52.0 [37.0-57.0] | |||
| Body Mass Index (kg/m²) | controls | 23.4 [21.3-25.5]; n=41 | <0.001 | 24.1 [21.5-26.0] | <0.001 |
| patients | 46.3 [42.0-50.8]; n=41 | 43.6 [41.0-49.3] | |||
| MitoPO2 (mmHg) | controls | 71.3 [59.9-80.9]; n=36 | 0.25 | 70.1 [61.3-80.4] | 0.29 |
| patients | 60.5 [47.8-78.0]; n=36 | 57.6 [50.0-68.8] | |||
| MitoVO2 (mmHg/s) | controls | 3.6 [2.3-4.8]; n=36 | 0.86 | 3.6 [2.9-5.7] | 0.97 |
| patients | 3.8 [2.4-5.1]; n=36 | 3.6 [2.4-5.1] | |||
| MitoDO2 (mmHg/s) | controls | 5.7 [4.6-7.6]; n=36 | 0.002 | 5.4 [4.3-7.6] | 0.29 |
| patients | 3.7 [2.4-5.9]; n=36 | 3.8 [2.7-6.3] | |||
| T3: 6 ± 1 months after surgery | |||||
| MitoPO2 (mmHg) | controls | 71.0 [59.4-80.6]; n=31 | 0.64 | 70.1 [61.3-80.4] | 0.29 |
| patients | 62.8 [47.9-76.1]; n=31 | 62.0 [47.9-73.2] | |||
| MitoVO2 (mmHg/s) | controls | 3.7 [2.3-5.6]; n=31 | 0.86 | 3.6 [2.9-5.7] | 0.74 |
| patients | 4.0 [2.9-4.7]; n=31 | 4.1 [2.6-4.7] | |||
| MitoDO2 (mmHg/s) | controls | 5.6 [4.3-7.3]; n=31 | 0.64 | 5.4 [4.3-7.6] | 0.68 |
| patients | 4.4 [3.2-6.9]; n=31 | 3.7 [3.0-7.1] | |||
| T5: 12 ± 1 months after surgery | |||||
| MitoPO2 (mmHg) | controls | 71.3 [60.3-81.9]; n=30 | 0.86 | 70.1 [61.3-80.4] | 0.78 |
| patients | 68.5 [58.8-91.3]; n=30 | 67.4 [57.8-91.7] | |||
| MitoVO2 (mmHg/s) | controls | 3.4 [2.4-4.5]; n=30 | 0.64 | 3.6 [2.9-5.7] | 0.29 |
| patients | 3.0 [2.3-4.4]; n=30 | 2.9 [2.1-3.8] | |||
| MitoDO2 (mmHg/s) | controls | 5.6 [4.4-7.3]; n=30 | 0.43 | 5.4 [4.3-7.6] | 0.68 |
| patients | 4.4 [3.2-6.3]; n=30 | 4.5 [3.4-6.0] | |||
All data in median [interquartile range]. Results are presented for all patients with available data and the trajectory patient sample with available data for all study visits. False-discovery rate adjusted p values < 0.05 (Wilcoxon signed-rank tests) are printed in bold.
mitoPO2, mitochondrial oxygen tension; mitoVO2, mitochondrial oxygen consumption; mitoDO2, mitochondrial oxygen delivery; PpIX-TSLT, Protoporphyrin IX-Triplet State Lifetime Technique.