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. 2025 Jan 7;14:1430793. doi: 10.3389/fonc.2024.1430793

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Copyright © 2025 Jelgersma, Alsolivany, Akkas, Wasilewski, Gastl, Misch, Capper, Kaul, Bullinger, Vajkoczy and Onken

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TTFields usage data, and therapy adherence. (A) Average usage of TTFields in the first-, second-, and third-line therapy (ANOVA, n.s.). (B) TTFields usage in the course of time in all included patients (mean of all patients during each cycle). (C) Showing the average (mean) therapy usage of patients before and after recurrence in the first-line therapy when TTFields was continued (red = dropping -, green = increasing usage, Student’s t-test, p = 0.0002). (D) Heat map of usage in % per cycle before and after recurrence in the same patients. Yellow to red indicates usage rates below 50%. (E, F) Showing usage parameter. (E) TTFields usage during day- and nighttime (Student’s t-test, p=0.0015). (F) Break days per cycle in different therapy lines (Student’s t-test, n.s.).