Table 2.
Known REV7 interactors.
| Protein | Function | Organism | Detection Method | Reference |
|---|---|---|---|---|
| 53BP1 | DDR, NHEJ | H | MS, CoIP | (221) |
| 911 Complex | DDR | Y | Y2H, P, CoIP | (222) |
| ADP | Adenovirus infection, cell lysis | H | Y2H, P, CoIP | (132) |
| CDC20 | APC/C, cell cycle regulation | H | Y2H, P, Co-IP | (82, 138, 223) |
| CDC27 | APC/C, cell cycle regulation | H | P, CoIP | (223) |
| CDH1 | APC/C, cell cycle regulation | H | P, CoIP | (5, 83, 84) |
| CDK1 | Cell cycle regulation, PGC | M | CoIP | (105) |
| CAMP/CHAMP1 | Cell cycle regulation, chromosome segregation | H | CoIP, MS, XRD | (15, 90, 224) |
| CLTA | Cell cycle regulation, chromosome segregation | H | Y2H, P, CoIP | (91, 225) |
| CST-Complex | DDR, NHEJ | H | Y2H, CoIP | (69) |
| DDK | TLS | Y | CoIP | (226) |
| ELK-1 | Transcription factor | H | Y2H, P, CoIP | (19) |
| EspF | E. coli virulence effector | EC | Y2H | (139) |
| G9A | Epigenetics, histone methyltransferase | M | CoIP | (105) |
| GLP | Epigenetics, histone methyltransferase | M | CoIP | (105) |
| HCCA2 | Transcriptional coactivator | H | Y2H, P, CoIP | (227) |
| HR23B | DDR, NER | H | MS, CoIP | (228) |
| IpaB | Cell cycle disruption by Shigella | H | Y2H, P, CoIP, XRD | (16, 138) |
| MAD2 | SAC, mitosis | H | Y2H, P, XRD | (4, 14) |
| MDC9/ADAM9 | Mitosis | H | Y2H, P | (229) |
| NCOA3 | Transcriptional coactivator | H | CoIP, MS | (165) |
| p31(comet) | Cell cycle regulation, SAC | H | Y2H, CoIP, XRD | (14, 22) |
| p53 | DDR, DSB | H | P | (230) |
| POLD2/Pol31 | TLS, Pol ζ | Y, H | Cryo-EM | (17) |
| POLD3/Pol32 | TLS, Pol ζ | Y, H | P, Cryo-EM | (17, 231) |
| PRCC | Cell cycle regulation | H | Y2H, FRET, CoIP | (232) |
| PRDX2 | Antioxidant, carcinogenesis | H | CoIP, MS | (175) |
| RAN | Cell cycle regulation | H | Y2H, P, CoIP, XRD | (16, 233) |
| REV1 | TLS | Y, M, H | Y2H, P, CoIP, Cryo-EM, XRD | (44, 234–239) |
| REV3 | TLS, Pol ζ | Y, M, H | Y2H, P, CoIP, Cryo-EM, XRD | (14, 235–237, 240, 241) |
| REV7 | TLS, Pol ζ, DSB | Y, M, H | Y2H, CoIP, NMR | (14, 68, 242) |
| SHLD1 | DSB, NHEJ | M, H | Y2H, P, Cryo-EM, MS, XRD | (66, 70, 73, 243–245) |
| SHLD2 | DSB, NHEJ | M, H | Y2H, P, Cryo-EM, MS, XRD | (66, 70, 73, 244–247) |
| SHLD3 | DSB, NHEJ | M, H | Y2H, CoIP, Cryo-EM, XRD | (73, 242, 246, 248, 249) |
| SIM2 | Transcription factor | R, H | Y2H, CoIP | (225) |
| TCF4 | Transcription factor | H | Y2H, P, CoIP | (18, 250) |
| TFII-I | Transcription factor | H | P, CoIP, MS | (251) |
| TRIP13 | Cell cycle regulation, chromosome segregation, SAC | H | CoIP, MS, Cryo-EM, XRD | (21, 22, 68, 246) |
REV7 interacts with proteins that perform a wide variety of functions. DDR, DNA damage response; NHEJ, non-homologous end joining; APC/C, anaphase-promoting complex/cyclosome; TLS, translesion synthesis; SAC, spindle assembly checkpoint; DSB, double-strand break; PGC, primordial germ cell. Interactions detected via co-immunoprecipitation (CoIP), fluorescence resonance energy transfer (FRET), GST-tagged pull-down (P), mass spectrometry (MS), X-ray diffraction (XRD), chromatin immunoprecipitation (ChIP), and/or yeast two-hybrid (Y2H). Organisms studied include human (H), mouse (M), rat (R), yeast (Y), and E. coli (EC).