Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Jul 7;33(12):3779–3784. doi: 10.1093/nar/gki682

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2005. Published by Oxford University Press. All rights reserved

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oupjournals.org

PMC Copyright notice

A model for the exclusion of 8-oxoGua-containing ribonucleotides from the RNA precursor pools in mammalian cells. 8-OxoGTP and 8-oxoGDP are interconvertible by the actions of nucleoside diphosphate kinase and nucleoside triphosphatase. Partial phenotypic suppression is caused by the misincorporation of 8-oxoGTP into RNA by RNA polymerase II. 8-OxoGDP is hydrolyzed to 8-oxoGMP by NUDT5 and MTH1, while 8-oxoGTP is cleaved directly to 8-oxoGMP by MTH1. 8-OxoGMP, a non-utilizable form for RNA synthesis, is further degraded to 8-oxoguanosine by nucleotidases. Nucleosides are readily transported through the cell membrane and can be excreted into the urine.