Table 1. Summary of DNA sequences with methylation changes identified by AIMS in MZ twin pairs.
CpG methylation,* %
|
|||||||
---|---|---|---|---|---|---|---|
Locus | Accession | Function | Chr. loc. | No. CpGs | Twin A | Twin B | Change |
Alu-Sx | AC006271 | – | 19p13.2 | 30 | 72.1 | 55.3 | 16.8 |
Alu-Sp | U14572 | – | 19p13+3 | 17 | 68.1 | 29.9 | 38.2 |
Alu-E2F3 | AF547386 | – | 6p22 | 2 | 81.8 | 100 | 18.2 |
PKD1P2 | NG_002795 | Polycystic kidney disease 1 | 16p13 | 7 | 90.9 | 83.5 | 7.4 |
Alu-Sc | U14571 | – | 8p11+1 | 4 | 66.6 | 63.3 | 3.3 |
GUK1 | BC006249 | Guanylate kinase 1 | 1q42 | 18 | 2.8 | 9.7 | 6.9 |
Chr. loc., chromosome location; –, unknown.
Twelve clones per locus