Table 2. Values of [125I]hCT binding inhibition and cAMP stimulation.
| [125I]CT binding inhibition IC50, pM | cAMP stimulation EC50, pM | |
|---|---|---|
| hCT | 3220 ± 240 | 231 ± 73* |
| sCT | 224 ± 25† | 131 ± 18*‡ |
| 6CH-R | 416 ± 40† | 96 ± 20*‡ |
| 6S | 408 ± 106† | 115 ± 27*‡ |
| 5P | 154 ± 34† | 48 ± 7 |
Results are means ± SEM. Binding and cAMP experiments were repeated three and six times, respectively. *, P < 0.05 versus 5P. †, P < 0.01 versus hCT. ‡, P < 0.05 versus hCT when treated as a group of peptides of equivalent potency.