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Effect of DAPA on meizothrombin accumulation. Total meizothrombin accumulation in the cleavage of IIWT (○), IITAT (•), and IIQ155,Q284 (▵) as a function of increasing concentrations of DAPA was estimated by integrating areas under progress curves and normalizing the value to the area under the mIIa progress curve with IIWT measured at 60 μM DAPA. The dashed line denotes a value of 1. The solid line was arbitrarily drawn.
