Table 7.
FBAT-e analyses considering 226 ankylosing spondylitis nuclear families (201 pedigrees, 894 persons): summary of results using setafftrait 1 -1 0
Marker | Allele | Allele frequency | Number of informative families | Z score | P |
Additive model: biallelic test | |||||
D5S1953 | 1 | 0.56 | 63 | 0.15 | 0.879 |
rs26307 | C | 0.81 | 35 | 1.29 | 0.195 |
rs27356 | C | 0.80 | 39 | 1.12 | 0.261 |
3088132 | G | 0.79 | 29 | 0.69 | 0.489 |
rs153929 | G | 0.24 | 52 | 0.61 | 0.541 |
rs258215 | T | 0.41 | 41 | 0.46 | 0.638 |
rs28006 | T | 0.26 | 44 | 1.69 | 0.090 |
rs25957 | G | 0.23 | 39 | 0.90 | 0.366 |
ANKH-OR | 1 | 0.48 | 80 | 0.20 | 0.841 |
D5S1991 | 1 | 0.52 | 80 | 0.29 | 0.769 |
D5S1954 | 2 | 0.36 | 63 | 1.21 | 0.227 |
Recessive model: biallelic test | |||||
D5S1953 | 1 | 0.56 | 46 | -0.89 | 0.370 |
rs26307 | C | 0.81 | 37 | 2.17 | 0.030* |
rs27356 | C | 0.80 | 41 | 1.91 | 0.055 |
3088132 | G | 0.79 | 29 | 1.17 | 0.240 |
rs153929 | G | 0.24 | 18 | 0.55 | 0.582 |
rs258215 | A | 0.59 | 29 | -0.75 | 0.453 |
rs28006 | C | 0.74 | 40 | -1.13 | 0.186 |
rs25957 | C | 0.77 | 36 | -0.66 | 0.507 |
ANKH-OR | 2 | 0.52 | 50 | -0.34 | 0.733 |
D5S1991 | 2 | 0.49 | 52 | -0.28 | 0.779 |
D5S1954 | 1 | 0.64 | 61 | -1.53 | 0.126 |
*Statistically significant findings. FBAT, family-based association testing.