Table 4.

Concentrations of inflammatory mediators in synovial fluid and plasma from arthritic patients (n = 11)

Mediator	Concentration		P
	Synovial fluid	Plasma
MCP-1 (pg/ml)	134 (36–522)	34 (15–62)	0.008
sICAM-1 (ng/ml)	706 (226–1,085)	871 (657–1,691)	0.006
IL-8 (pg/ml)	614 (<50–24,630)	<50	0.002
IL-6 (pg/ml)	13,897 (35–43,131)	11 (0–57)	0.002
VEGF (pg/ml)	1,604 (528–2,506)	23 (<5–69)	0.002
RANTES (pg/ml)	7 (<5–35)	3,986 (2,920–10,037)	0.001
GM-CSF (pg/ml)	<2 (<2–39)	<2 (<2–28)	0.125

Results are medians, with ranges in parentheses. Concentrations of all mediators were determined by ELISA as described in the Materials and methods section. GM-CSF, granulocyte/macrophage colony-stimulating factor; MCP-1, monocyte chemoattractant protein-1; sICAM-1, soluble intracellular adhesion molecule-1; VEGF, vascular endothelial growth factor.