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. 2005 Jun 30;102(28):9884–9889. doi: 10.1073/pnas.0504391102

Fig. 3.

Fig. 3.

Portosystemic shunting in Tie2-tTA/TRE-int3 mice. (A–F) Liver vascular casts of control (A, C, and E) and Tie2-tTA/TRE-int3 (B, D, and F) mice at the indicated age postweaning (PW). Arrowheads, hepatic arteries; arrows, connections between portal (p) and central (c) veins. Central veins were distinguished from portal veins by the absence of adjacent hepatic arteries. (Scale bars, 0.2 mm.) (D Inset) A higher magnification of the shunt. (G–R) Light and fluorescence photomicrographs after portal vein microsphere injections into control (G, I, K, M, O, and Q) and Tie2-tTA/TRE-int3 (H, J, L, N, P, and R) mice. Li, liver; Lu, lung.