Table 1.
Serological markers of inflammation and histopathological findings were not significantly affected by ovariectomy
| Arthritis | OVX | No. of mice | IgG (mg/ml) | CII antibody (ng/ml) | Interleukin-6 (pg/ml) | Frequency of arthritis, day 45 (%) | Arthritic score, day 45 | Histopathology (score) |
| - | - | 10 | 10 (10–12) | n.d | 62 (48–67) | 0 | 0 | 0 |
| + | 10 | 10 (7–15) | n.d | 80 (42–111) | 0 | 0 | 0 | |
| + | - | 18 | 18 (15–23) | 4.6 (2.6–8.0) | 343 (214–755) | 100 | 8 (7–10)*** | 9.5 (7.0–11.5) |
| + | 15 | 18 (15–18) | 3.5 (2.3–4.6) | 371 (280–602) | 100 | 11 (10–12) | 11.0 (8.9–13.0) |
Values are medians and interquartile ranges for each group. The maximum arthritic score was 12 points per mouse. ***P < 0.001 between sham-operated and ovariectomized arthritic mice. CII, type II collagen; n.d., not detectable; OVX, ovariectomy.