Table 1.
Summary of adhesion molecules and chemokines/cytokines differentially expressed in CIA joints at early stages of disease and their GO terms.
| Affymetrix ID | Change | Gene ID | Description | Go Term/Function |
| Solely changed in comparison CFA/collagen II versus CFA | ||||
| 1423760_at | Up | Cd44 | CD44 antigen | GO:0007155 cell adhesion |
| Solely changed in comparison CFA/collagen II versus no treatment | ||||
| 1422103_a_at | Dn | Stat5b | Signal transducer and activator of transcription 5B | GO:0030155 cell adhesion |
| 1423166_at - | Dn | Cd36 | CD36 antigen | GO:0007155 cell adhesion |
| 1427165_at - | Up | Il13ra1 | IL-13 receptor alpha 1 | GO:0004907 IL activity |
| 1434044_at - | Dn | Repin1 | Replication initiator 1 | GO:0006954 inflammatory response |
| 1452483_a_at | Up | Cd44 | CD44 antigen | GO:0007155 cell adhesion |
| 1452514_a_at | Dn | Kit | Kit oncogene | GO:0006935 chemotaxis |
| Solely changed in comparison CFA versus no treatment | ||||
| 1416156_at | Dn | Vcl | Vinculin | GO:0005912 adherens junction |
| 1417705_at | Dn | Otub1 | OTU domain, ubiquitin aldehyde binding 1 | GO:0006955 immune response |
| 1422873_at | Dn | Prg2 | Proteoglycan 2, bone marrow | GO:0006955 immune response |
| 1430375_a_at | Up | Ccl27 | Chemokine (CC motif) ligand 27 | GO:0008009 chemokine activity |
| 1437807_x_at | Dn | Catna1 | Catenin α1 | GO:0005912 adherens junction |
| 1452020_a_at | Up | Siva | CD27 binding protein | GO:0005175 CD27 receptor binding |
| 1455158_at | Dn | Itga3 | Integrin α3 | GO:0007155 cell adhesion |
| Changed in comparisons CFA/collagen II vs. CFA and CFA vs. no treatment | ||||
| 1450488_at | Dn-Up | Ccl24 | Chemokine (CC motif) ligand 24 | GO:0008009 chemokine activity |
| Changed in comparisons CFA/collagen II vs. no treatment and CFA vs. no treatment | ||||
| 1419329_at | Dn Dn | Sh3d4 | SH3 domain protein 4 | GO:0007155 cell adhesion |
| 1420465_s_at | Up Up | Mup1 | Major urinary protein 1 | GO:0016068 type I hypersensitivity |
| 1420553_x_at | Dn Dn | Serpina1a | Serine proteinase inhibitor, clade A, member 1a | GO:0006953 acute-phase response |
| 1423017_a_at | Up Up | Il1rn | IL-1 receptor antagonist | GO:0006955 immune response |
| 1423734_at | Up Up | Rac1 | RAS-related C3 botulinum substrate 1 | GO:0007155 cell adhesion |
| GO:0006954 inflammatory response | ||||
| 1423885_at | Dn Dn | Lamc1 | Laminin γ1 | GO:0007155 cell adhesion |
| 1427164_at | Up Up | Il13ra1 | IL-13 receptor α1 | GO:0004907 IL activity |
| 1435148_at | Dn Dn | Atp1b2 | ATPase, Na+/K+ transporting, β2 polypeptide | GO:0007155 cell adhesion |
| 1448303_at | Dn Dn | Gpnmb | Glycoprotein nmb | GO:0007155 cell adhesion |
| 1451767_at | Up Up | Ncf1 | Neutrophil cytosolic factor 1 | GO:0006954 inflammatory response |
Shown are differentially expressed genes associated with adhesion or inflammation with respect to Gene Ontology (GO) terms. The genes are a subset of those shown in the Venn diagram (Fig. 1). The first column gives the probe set identification number (ID) of the Affymetrix chip Moe430a. The second column lists whether the gene is significantly upregulated (Up) or downregulated (Dn; minimum 1.5-fold) in a particular comparison, ordered complete Freund's adjuvant (CFA)/collagen II versus CFA, CFA/collagen II versus no treatment, and CFA versus no treatment. Columns three to five show the gene symbol, its name and GO terms. For further details, see Materials and method. IL, interleukin.