Figure 2.

Serological and urinary markers of collagen-induced arthritis. (Panel 2) The serum albumin concentration was negatively correlated with the production of acute-phase proteins such as C-reactive protein (CRP) (top panel). (Panel 3) Alkaline phosphatase (AP) is mainly produced by liver and osteoblasts. When liver function is normal, changes in AP can be indicative of bone remodeling processes as a result of bone degradation. (Panels 4,5) Increased urinary excretion rates of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) cross-link products, expressed relative to creatinine (Cr), were observed during the active phase of the disease. Each data point in the graphs is a mean of at least 3 animals for group I (n = 6) and 5 animals for groups II and III (n = 12 and n = 13, respectively). Squares, early responders (group I); triangles, intermediate responders (group II); circles, late responders (group III).