Table 2.
Association of MMP12 A-82G and A1082G polymorphisms with breast cancer risk
| MMP12 genotype | Cases | Controls | Crude OR (95% CI) | Adjusted ORa (95% CI) |
| No. (%) | No. (%) | |||
| A-82G | ||||
| AA | 1063 (95.1) | 1153 (94.3) | 1.0 | 1.0 |
| AG | 51 (4.6) | 69 (5.6) | 0.9 (0.6–1.2) | 0.9 (0.6–1.3) |
| GG | 4 (0.3) | 1 (0.1) | ||
| A1082G (Asn357Ser) | ||||
| AA | 739 (80.2) | 784 (80.3) | 1.0 | 1.0 |
| AG | 159 (17.2) | 175 (17.9) | 1.0 (0.8–1.3) | 1.0 (0.8–1.3) |
| GG | 24 (2.6) | 17 (1.8) | ||
| Presence of any minor genotypesb | ||||
| No | 687 (75.4) | 731 (75.4) | 1.0 | 1.0 |
| Yes | 224 (24.6) | 239 (24.6) | 1.0 (0.8–1.2) | 1.0 (0.8–1.2) |
aAdjusted for age, education, age at menarche, menopausal status, age at menopause, age at first live birth, waist-to-hip ratio, and physical activity during past 10 years. bAG/GG genotypes for A-82G and AG/GG genotype for A1082G polymorphisms. CI, confidence interval; OR, odds ratio.