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. 2005 Jul 5;389(Pt 2):249–257. doi: 10.1042/BJ20050051

Table 1. Different functions of SAPLIPs and their sources.

(a) Autonomous domains
Function Organism
Lipid catabolism/transfer
 Saposins A, B, C, D Sphingolipid catabolism and antigen presentation Homo sapiens, Equus caballus, Bos taurus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Xenopus laevis
Surfactant stabilization
 Surfactant protein B Surfactant stabilization Homo sapiens, Canis familiaris, Mus musculus, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus
Defence proteins
 Granulysin Antimicrobial and cytolytic activity Homo sapiens
 NK-lysin Sus scrofa
 NK-lysin orthologues Equus caballus, Bos taurus
 Amoebapores Entamoeba histolytica
 Amoebapore orthologues Entamoeba dispar, Entamoeba invadens
 Amoebapore-like protein Fasciola hepatica
 Naegleriapores Naegleria fowleri
 Clornorin Clonorchis sinensis
Cell proliferation regulation
 Prosaposin Lipid transfer, neurite outgrowth and apoptosis regulation Homo sapiens, Equus caballus, Bos taurus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Xenopus laevis
 MSAP Neurite outgrowth Homo sapiens
(b) Multidomain proteins
Function Organism
Lipases
 Metallophosphoesterases (e.g. acid sphingomyelinase) Sphingomyelin hydrolysis Homo sapiens, Caenorhabditis elegans, Ciona intestinalis, Anopheles, Drosophila, Mus musculus, Rattus norvegicus
 GDSL (Gly-Asp-Ser-Leu) lipase (e.g. acyloxy hydrolase) LPS deacetylation Homo sapiens, Rattus norvegicus
Stage regulation
 Countin Cell number counting Dictyostelium discoideum
Crystallin
 J3-crystallin Crystallin Tripedalia cystophora
Proteases
 Plant aspartic proteases Proteolytic degradation defence Viridiplantae