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. 2001 Dec 26;99(1):66–71. doi: 10.1073/pnas.012606199

Figure 2.

Figure 2

Effect of C75 on food intake and blood glucose and insulin levels in ob/ob mice. ob/ob mice (n = 12) were divided into three groups on the basis of initial blood glucose level. Mice were either fasted (n = 4) (■) or were treated with vehicle (n = 4) (control) (●) or C75 (27 mg/kg body weight) (n = 4) (▴) by i.p. injection and fed ad libitum. After injection (3 h before “lights off”), food consumption was measured at 1-h intervals for 6 h (a). Blood glucose and insulin levels were measured 18 h after injection (c and d, respectively). Food consumption was measured 24 h after injection (b). Values are shown as means ± SEM. The blood glucose and insulin levels of lean (C57BL/6J) mice were 170 ± 6 mg/dl and 1.4 ± 0.7 ng/ml, respectively. In c and d, □ indicates prevalue and ■ indicates after treatment; *, P < 0.05, **, P < 0.01, and ***, P < 0.001 vs. control group; †, P < 0.05 and ††, P < 0.01 vs. prevalue of each group.