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. 2024 Dec 14;43:e00444. doi: 10.1016/j.plabm.2024.e00444

Table 2.

Measures of diagnostic accuracy for PCT, CD64 and CRP for detection of septic patients who received antimicrobial therapies, using the optimum cutoff values.

AUC (95 % CI) P value Cut-off Sensitivity (95 % CI) Specificity (95 % CI) PPV (95 % CI) NPV (95 % CI) LR+ (95%CI) LR–(95%CI)
PCT 0.726 (0.689–0.762) <0.001 0.08 ng/ml 75.8 (70.3–80.7) 62.9 (57.4–68.2) 63.8 (60.1–67.4) 75.1 (70.7–79.1) 2.05 (1.7–2.4) 0.38 (0.3–0.5)
CD64 0.692 (0.651–0.732) <0.001 1.70 47.2 (41.0–53.6) 84.5 (79.5–88.6) 74.5 (68.2–80.0) 62.5 (59.4–65.4) 3.04 (2.2–4.1) 0.62 (0.5–0.7)
CRP 0.719 (0.682–0.754) <0.001 >69 mg/L 51.1 (45.1–57.0) 83.6 (79.2–87.4) 72.4 (66.7–77.4) 67.1 (64.2–69.8) 3.12 (2.4–4.1) 0.59 (0.5–0.7)

PCT, procalcitonin; CD64, neutrophil CD64; CRP, C-reactive protein (CRP).

PCT vs CRP, z = 0.543, p = 0.587.

CD64 vs CRP, z = 0.892, p = 0.373.

PCT vs CD64, z = 1.149, p = 0.251.