Fig. 5.

Gaucher Disease, bone marrow trephine section. There is a focal infiltrate of macrophages (top, centre) which have the typical “onion skin” or “watered silk” texture to the cytoplasm. This is due to the accumulation of glucosylceramide in the macrophage. The remainder of the trephine is comprised of normal hematopoietic tissue. (H&E, x200), Courtesy of Dr M Jeffers.