Table 3.

Univariate and multivariate analysis of factors affecting RFS and CSS in ESCC patients after IPTW.

Characteristic	RFS				CSS
	Univariate	P value	Multivariate	P value	Univariate	P value	Multivariate	P value
	HR (95% CI)		HR (95% CI)		HR (95% CI)		HR (95% CI)
Sex
Female
Male	0.76 (0.49-1.20)	0.244			0.82 (0.52-1.31)	0.412
Age
≤65
>65	1.01 (0.65-1.58)	0.955			0.94 (0.58-1.52)	0.803
BMI (kg/m2)
≤18.5
18.5-25	0.83 (0.47-1.46)	0.511			0.75 (0.42-1.34)	0.328
≥25	0.65 (0.34-1.24)	0.194			0.59 (0.30-1.16)	0.126
Histologic grade
Gx/G1
G2	0.96 (0.67-1.38)	0.833			0.93 (0.65-1.34)	0.712
G3	1.60 (0.95-2.70)	0.075			1.47 (0.84-2.57)	0.173
Tumor location
Proximal
Mid	0.78 (0.38-1.58)	0.487			0.73 (0.34-1.53)	0.401
Distal	0.90 (0.43-1.86)	0.768			0.83 (0.38-1.80)	0.643
T stage
T1
T2	1.88 (0.98-3.60)	0.056	1.37 (0.71-2.63)	0.348	1.96 (1.01-3.80)	0.047	1.39 (0.72-2.67)	0.326
T3	3.28 (1.95-5.50)	<0.001	2.62 (1.51-4.56)	0.001	3.28 (1.93-5.59)	<0.001	2.59 (1.48-4.51)	0.001
T4a	5.21 (1.78-15.21)	0.003	5.43 (2.35-12.56)	<0.001	5.42 (1.77-16.57)	0.03	4.54 (1.17-17.70)	0.029
N stage
N0
N1	2.17 (1.40-3.38)	0.001	2.49 (1.58-3.94)	<0.001	2.17 (1.37-3.43)	0.001	2.37 (1.45-3.86)	0.001
N2	3.58 (2.35-5.46)	<0.001	2.90 (1.79-4.71)	<0.001	3.52 (2.26-5.47)	<0.001	2.90 (1.78-4.72)	<0.001
N3	3.92 (1.72-8.95)	0.001	3.73 (1.90-7.32)	<0.001	3.72 (1.71-8.09)	0.001	2.71 (1.24-5.92)	0.012
Lymphadenectomy
Two-field
Three-field	0.94 (0.62-1.44)	0.785			0.96 (0.63-1.46)	0.831
Surgical procedure
McKeown
Ivor Lewis	0.89 (0.52-1.51)	0.666			0.88 (0.51-1.53)	0.652
ISS
Low
High	4.74 (3.30-6.82	<0.001	6.17 (4.24-8.98	<0.001	5.82 (3.91-8.67)	<0.001	7.08 (4.66-10.75	<0.001